N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide

N-(4-chlorophenyl)-2‑[(pyridin‑4‑ylmethyl)amino]benzamide is a synthetic small molecule classified as a benzanilide derivative. It acts as an inhibitor of vascular endothelial growth factor receptors (VEGFR), specifically targeting both VEGFR1 and VEGFR2 tyrosine kinases. By inhibiting these receptors, the compound blocks downstream signaling pathways involved in angiogenesis—the formation of new blood vessels—which is a key process in tumor growth and metastasis. This mechanism makes it relevant for research into anti-cancer therapies, particularly those aimed at suppressing tumor vascularization[2][5][9]. The compound is primarily used as a biochemical tool or reference inhibitor in preclinical studies rather than as an approved pharmaceutical product.

Other names

N-(4-chlorophenyl)-2-{[(pyridin-4-yl)methyl]amino}benzamideN-(4-Chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamideBenzamide, N-(4-chlorophenyl)-2-[ (4-pyridinylmethyl)amino ]-DTXSID60430900DTXSID-60430900DTXSID 60430900DTXCID30381733DTXCID-30381733DTXCID 30381733269390–69–4CHEMBL101683CHEMBL-101683CHEMBL 101683ZINC000000008732ZINC-000000008732ZINC 000000008732